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Mathematical modeling of bacterial metabolism

A.N. Golomysova$^1$, M. Gomelsky$^2$, P.S. Ivanov$^1$

Moscow University Physics Bulletin 2010. 65. N 3. P. 230

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Annotation

A variant of mathematical model construction for the anaerobic metabolism of a purple nonsulfur bacterium based on a flux balance analysis is presented in this paper. The model includes all the central metabolic pathways of the bacterial cell, as well as pathways for biosynthesis of amino acids and bacteriochlorophyll. It is shown that the results of modeling of bacterial photoheterotrophic growth on acetate agree with experimental values for the known metabolite pathways, which shows that the constructed model adequately describes actual cellular processes.

Received: 2009 December 25
Approved: 2010 June 23
PACS:
87.17.Aa Modeling, computer simulation of cell processes
Rissian citation:
А.Н. Голомысова, М. Гомельский, П.С. Иванов.
Математическое моделирование бактериального метаболизма.
Вестн. Моск. ун-та. Сер. 3. Физ. Астрон. 2010. № 3. С. 73.
Authors
A.N. Golomysova$^1$, M. Gomelsky$^2$, P.S. Ivanov$^1$
$^1$Department of Biophysics, Faculty of Physics, Moscow State University, Moscow, 119991, Russia
$^2$Department of Molecular Biology, University of Wyoming, E. University Ave., Dept. 3944, Laramie, WY, 82071, USA
Issue 3, 2010

Moscow University Physics Bulletin

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