Experimental data to confirm the possibility of the usage of polysaccharides as adjuvants were obtained. Immunoadjuvant activity of polysaccharide ADVA when used in conjunction with antigens of different structures and chemical natures: sheep red-blood cells, meningococcal polysaccharide antigen, tetanus exotoxin protein, and hemagglutinin of influenza virus were studied. The structure of the polysaccharide ADVA was characterized by the IR-spectroscopy and GC methods. It was shown that ADVA is non-toxic. The possibility of using ADVA as an immunoadjuvant is discussed.
87.14.-g Biomolecules: types
Department of Biophysics, Faculty of Physics, Moscow State University, Moscow, 119991, Russia
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