A mathematical model has been constructed and studied of the penetration of hematoporphyrin (HP) ions into cells and their accumulation there. HP is a photosensitizer most frequently used in the photodynamic therapy of tumors. It is shown that the selectivity of HP accumulation in tumors depends on the following factors: {a) the lowered acidity inside malignant cells and in the surrounding medium and {b) the higher concentration in tumor cells of lipids, to which the HP molecules bind.
Department of General Physics and Wave Processes, Faculty of Physics, Moscow State University, Leninskie Gory, Moscow, 119992, Russia
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