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Changes in the mechanical and electric parameters of bilayer lipid membranes in their interaction with hematoporphyrin

T. Hianik$^1$, D. Masarikova$^1$, L.V. Zhorina$^2$, M.Yu. Poroshina$^2$, E.B. Chernyaeva$^2$

Moscow University Physics Bulletin 1992. 47. N 1. P. 59

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Annotation

The interaction of hematoporphyrin IX (HP) with artificial bilayer lipid membranes (BLMs) has been studied. It has been found that after dark incubation of BLMs in a HP solution (at concentrations from $10^{-6}$ to $3 \cdot 10^{-5}$ M) the conductance of the BLMs does not change very much, the elasticity modulus ( $E_{\perp}$ ) and the dynamic viscosity coefficient $\eta$ diminish by 21.9-31.3%, while the membrane potential $U_1$ becomes negative (-50 mV). Irradiation of a modified BLM by a He-Ne laser leads to an increase of the parameters $E_{\perp}$ aud $\eta$ by 40.7 to 66.2%, to a decrease of $U_1$ to -20 mV, and also to irreversible changes in the mechanical properties of the membrane. Binding of HP with BLM proceeds noncooperatively with the constant $К = 10^{5}$ $М^{-1}$.

Authors
T. Hianik$^1$, D. Masarikova$^1$, L.V. Zhorina$^2$, M.Yu. Poroshina$^2$, E.B. Chernyaeva$^2$
$^1$Faculty of Mathematics and Physics, Komenius University, Bratislava. Czechoslovakia
$^2$Department of General Physics and Wave Processes, Faculty of Physics, Moscow State University, Leninskie Gory, Moscow, 119992, Russia
Issue 1, 1992

Moscow University Physics Bulletin

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