MECHANISMS OF TEMPERATURE COMPENSATION IN THE MODELS OF BIOCHEMICAL OSCILLATIONS

Абстракт. Different mechanisms of temperature compensation of the frequency (period) of biochemical self-oscillations are considered. It is shown that system approach to clarification of the molecular nature of temperature compensation the frequency of biochemical self-oscillations more reasonable. The phenomenon of temperature compensation it is inherent not only for circadian oscillations ("biochemical clocks"), this is property of all multidimensional chemical oscillators. It is found out that stages with negative control coefficients over frequency are included into structure of "the setting generators" of biochemical self-oscillations and the balancing role of these stages more significantly. By calculation of control coefficients it is shown that significance of elementary stages in the mechanism of temperature compensation not equal and they are defined not only of control coefficients, and also depend on corresponding energy of activation. Therefore, different mutations differently influence temperature compensation of the period of circadian oscillations in different mutants